South Africa claimed a convincing 107-run victory as England collapsed again on the fourth day of the first Test in Centurion.
The tourists, needing to complete a record chase of 376, resumed on 121-1 but were bowled out for 268, with Kagiso Rabada taking 4-103.
A collapse of 7-64 sealed victory for South Africa, despite 84 from Rory Burns and Joe Root’s 48.
The second Test of the four-match series begins on Friday in Cape Town.
It would have required a huge effort from England to secure victory on a wearing pitch but once the second new ball was taken, wickets fell quickly.
While both Root and Jos Buttler were able to bat despite being ill on Saturday, no batsman could produce an innings of substance to anchor England’s chase.
South Africa were patient throughout the morning session and pressed home their advantage after lunch to secure their first victory in five Tests.