Brazil became the first South American nation to qualify for the 2022 World Cup with a 1-0 home win over Colombia.
Lucas Paqueta scored the only goal at Neo Quimica Arena in Sao Paulo for the five-time World Cup winners.
The Lyon midfielder, 24, finished off a move involving Paris St-Germain pair Marquinhos and Neymar on 72 minutes.
Brazil still has six qualifiers to play, but have dropped just two points from their 12 games and are nine points clear of second-placed Argentina.
“This is the result of all the hard work we’ve been putting in,” Paqueta told Brazilian television network SporTV.
“Qualifying for the World Cup was our main objective and we achieved that today.”
Brazil’s next qualifier is away to Argentina in San Juan on Tuesday (23:30 GMT).
Meanwhile, Wales’ 2022 World Cup play-off has been confirmed as Spain beat Greece 1-0.
Wales started their qualifying campaign knowing they had all but secured a playoff spot having won their Nations League group.
Spain’s win in Athens formally seals it, even if Wales finish outside the top two in their qualifying group.
Wales must finish second to have any chance of being seeded for March’s play-offs.
Teams who reach the play-offs via the Nations League are unseeded and will be away in their semi-final to a seeded nation.
Wales can guarantee a top-two finish with four points from their final two qualifiers at home to Belarus on Saturday and Belgium on Tuesday.
Wales could theoretically qualify automatically – they are five points behind Group E leaders Belgium with two games to go – but they would need the world’s number one ranked side to lose to Estonia as well as to Rob Page’s men in Cardiff.
Culled from BBCSports